Qin C., Zhang H., Zhao L., Zeng M., Huang W., Fu G., et al.. (2018). Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis. Sci. China Life Sci. 61 ( 12), 1537–1544. 10.1007/s11427-017-9202-0

Berberine benefits, dosage, and side effects - Examine Berberine benefits, dosage, and side effects - Examine

It also exerts a potent level of control over poorly regulated blood sugar, which is characteristically seen in type two diabetes and metabolic syndrome. Zhu L., Zhang D., Zhu H., Zhu J., Weng S., Dong L., et al.. (2018). Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe-/- mice. Atherosclerosis 268, 117–126. 10.1016/j.atherosclerosis.2017.11.023Zhang X., Zhao Y., Xu J., Xue Z., Zhang M., Pang X., et al.. (2015). Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Sci. Rep. 5:14405. 10.1038/srep14405 The “one-drug-multiple-target” concept is characteristic of the treatment applied for hyperlipidemia. The main targets of berberine on the metabolism of lipids and glucose are IR and the LDLR. Interestingly, berberine has been shown to reduce the serum levels of lipids in humans, hamsters, rats, and mice ( Kong etal., 2004; Chang etal., 2010; Wang etal., 2010). A clinical trial showed that berberine treatment reduced the levels of total cholesterol, triglycerides, and LDL cholesterol, while increasing the levels of HDL cholesterol after 3 months of treatment when compared with a placebo ( Derosa etal., 2013). Berberine’s potential for controlling blood sugar, blood lipids, and other indicators of your body’s metabolic health is quite strong, making it one of the most exciting herbal supplements on the market right now. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China [email protected] (H.-X.C.). [email protected]. Cicero A. F., Baggioni A. (2016). Berberine and Its Role in Chronic Disease. Adv. Exp. Med. Biol. 928, 27–45. 10.1007/978-3-319-41334-1_2

Berberine A safer hypoglycemic agent for type 2 diabetes—Berberine

Cui H. X., Hu Y. N., Li J. W., Yuan K. (2018. a). Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress. Oxid. Med. Cell Longev. 2018, 8930374. 10.1155/2018/8930374 Though it’s branded as clinical grade, this berberine supplement doesn’t appear to be of higher dosage or quality than anything else on the market. The global obesity epidemic is prompting significant efforts to identify host and environmental factors that affect energy balance in the human body. For example, Turnbaugh etal. reported that host obesity is related to an increase in the intestinal F:B ratio ( Turnbaugh etal., 2006). Berberine has been shown to revert the structural changes in the GM induced by a high-fat diet and regulate diversity in the GM. Berberine has also been shown to change 134 operational taxonomic units (OTUs) that were identified by nearest shrunken centroids analysis in obese rats induced by a high-fat diet, and was also associated with changes in obesity phenotypes. Sixty of the 134 OTUs were significantly increased with berberine treatment, particularly those belonging to putative SCFA-producing bacteria, including Allobaculum, Bacteroides, Blautia, Butyricicoccus, and Phascolarctobacterium. Strober W., Fuss I., Mannon P. (2007). The fundamental basis of inflammatory bowel disease. J. Clin. Invest. 117 ( 3), 514–521. 10.1172/JCI30587Hyperlipidemia is a major component of the metabolic syndrome, and gives rise to increased levels of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), while reducing the serum levels of high-density lipoprotein cholesterol (HDL-C) ( Chen etal., 2014). Berberine has been shown to exert a therapeutic effect on patients with hyperlipidemia ( Kong etal., 2004).

Berberine: Uses, Benefits, Side Effects, Dosage, Precautions

Wang L. L., Guo H. H., Huang S., Feng C. L., Han Y. X., Jiang J. D. (2017). Comprehensive evaluation of SCFA production in the intestinal bacteria regulated by berberine using gas-chromatography combined with polymerase chain reaction. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 1057, 70–80 of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China moc.361@4791nixgnohiuc (H.-X.C.); moc.621@888102nanayuh (Y.-N.H.) NOW Supplements makes a pretty solid berberine supplement that’s specifically geared towards using berberine for blood sugar control.You should talk to your doctor first if you take metformin (or any other prescription drug) and would also like to try berberine alongside it to better control your blood sugar.