Lemsip Max All in One Liquid 160ml

Product Information

Sympathomimetic amines: concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of cardiovascular side effects. If you're taking medicines for high blood pressure you shouldn't take Beechams all in one, because the decongestant may make your blood pressure medicine less effective. Ask your doctor or pharmacist for advice before taking this product if you are pregnant or breast-feeding. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.

Paracetamol is thought to relieve pain by reducing the production of prostaglandins in the brain and spinal cord. It works to bring down a fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). This stops you feeling hot or shivery. Use during breastfeeding should be avoided, unless recommended by a healthcare professional (see section 4.6). The content of sorbitol in medicinal products for oral use may affect the bioavailability of other medicinal products for oral use administered concurrently.The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of paracetamol with increased risk of bleeding; occasional doses have no significant effect. Many other cough, cold and flu remedies are available to buy without a prescription. Many of these will also contain paracetamol, guaifenesin and phenylephrine among their ingredients. Women who are pregnant. (Phenylephrine has blood vessel constricting effects that could restrict blood supply to the placenta, or cause problems for women with a history of pre-eclampsia. Ask your doctor or pharmacist for further advice on how to treat cold and flu symptoms during pregnancy.) Adults aged 16 years and over should take one dose of 10ml to 20ml up to four times a day as needed. Leave at least four hours between doses. Do not take more than four doses in 24 hours. Each dose should be measured using the measuring cup provided with the liquid.

Paracetamol: Paracetamol is absorbed rapidly and completely from the small intestine, producing peak plasma levels after 15-20 minutes following oral dosing. The systemic availability is subject to first-pass metabolism and varies with dose between 70% and 90%. The drug is rapidly and widely distributed throughout the body and is eliminated from plasma with a T½ of approximately 2 hours. The major metabolites are glucuronide and sulphate conjugates (>80%) which are excreted in urine.Caution should be taken when paracetamol is used concomitantly with flucloxacillin as concurrent intake has been associated with high anion gap metabolic acidosis, especially in patients with risks factors (see section 4.4) Guaifenesin been linked with an increased risk of neural tube defects in a small number of women with febrile illness in the first trimester of pregnancy. Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema, and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. It's fine to take Lemsip max all in one liquid with plain ibuprofen or aspirin (assuming these are appropriate for you). However, don't take it with co-codamol, co-dydramol or Tramacet because these contain paracetamol.