Solgar Inositol 500 mg Vegetable Capsules - Vitamin B8 - Vegan, Vegetarian, Kosher, 50 Count (Pack of 1)

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V., et al., Effects of myo-inositol in women with P14OS: a systematic review of randomized controlled trials. Gynecol Endocrinol, 2012. 28(7): p. 509-15. F., et al., Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials. Gynecol Endocrinol, 2019. 35(3): p. 198-206. Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 2013 95 1811–1827. 10.1016/j.biochi.2013.05.011 Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I Role of Inositols and Inositol Phosphates in Energy Metabolism. Molecules. (2020-Nov-01)

Gerli S, Mignosa M, et al. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2003 Nov-Dec; 7(6):151-9. Myo-inositol is one of nine different types of inositol. It is a naturally occurring substance produced in the human body from glucose, although it is not a sugar. Better described as a ‘vitamin-like’ substance, myo-inositol is often considered to be a member of the B complex group of vitamins. However, because it is produced by the body in amounts considered sufficient to support health, it is not officially termed an essential nutrient. In addition to the body’s own production from glucose, myo-inositol is also found naturally in many foods such as organ meats, fruit, grains, nuts and beans. Another study in 20 overweight women with PCOS found that 12 weeks of supplementation with myo-inositol improved insulin sensitivity and reproductive hormone balance and completely restored the menstrual cycle in all amenorrheic and oligomenorrheic subjects. 14

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X.Y., et al., Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with genetic susceptibility to polycystic ovary syndrome: A PRISMA-compliant meta-analysis. Gene, 2019. 719. With 750mg inositol in each of these capsules, it’s easier than ever to supplement your daily inositol intake.

Baillargeon JP, Iuorno MJ et al. Uncoupling between insulin and release of a D-chiro-inositol-containing inositol phosphoglycan mediator of insulin action in obese women with polycystic ovary syndrome. Metab Syndr Relat Disord. 2010 Apr;8(2):127-36.

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Many meta-analyses now show that inositol supplements are as effective as metformin for a range of biomarkers. These include insulin sensitization, testosterone levels, body mass index, and menstrual frequency [ 46, 47]. Women with PCOS are at a higher risk of several diseases and can experience infertility issues ( 15). Join my free 30-Day PCOS Diet Challenge here. This is a unique program where you'll receive weekly meal plans, shopping lists, and helpful video lessons. You'll also be part of a motivated and inspiring community of like-minded women. Nordio M, Basciani S, Camajani E. The 40: 1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios. Eur Rev Med Pharmacol Sci. 2019;23(12):5512-21. doi:10.26355/eurrev_201906_18223

Depression Symptoms - Nierenberg AA, Ostacher MJ, Calabrese JR, Ketter TA, Marangell LB, Miklowitz DJ, Miyahara S, Bauer MS, Thase ME, Wisniewski SR, Sachs GS Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone Am J Psychiatry. (2006 Feb)

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Periods: People with PCOS can have irregular periods or no periods at all. Treatment with inositols has been shown to help improve insulin sensitivity and reduce male hormone levels in females with PCOS. This helps restore periods. E.J., et al., Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA). Br J Nutr, 2018. 120(1): p. 111-120. Schizophrenia symptoms - Levine J, Goldberger I, Rapaport A, Schwartz M, Schield C, Elizur A, Belmaker RH, Shapiro J, Agam G CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia Eur Neuropsychopharmacol. (1994 Dec)