While care has been taken to ensure that the information prepared by CADTH in this document is accurate, complete, and up-to-date as at the applicable date the material was first published by CADTH, CADTH does not make any guarantees to that effect. CADTH does not guarantee and is not responsible for the quality, currency, propriety, accuracy, or reasonableness of any statements, information, or conclusions contained in any third-party materials used in preparing this document. The views and opinions of third parties published in this document do not necessarily state or reflect those of CADTH. Authorisation to return products damaged during delivery must be requested within 3 days of delivery. VWR has the right to repair and return damaged products. Follow-up telephone surveys were available for 99% (168/170) on Day 1, 99% (168/170) on Day 5, and 94% (160/170) on Day 14 postvaccination

A power calculation was performed, but the study did not recruit enough participants to meet this threshold and to appropriately measure to main outcome. Rather, the researchers powered it for the secondary outcome (i.e., incidence of delayed pain). Although the authors indicated that it was not feasible to recruit a sufficient number of patients for the primary outcome, this may limit the interpretation of results and conclusion of the study.

Where delivery or performance dates are stated by VWR these are estimates only and time is not of the essence; however, if VWR needs to change such dates it will do so only after providing information to the customer and having regards to the customer’s stated objectives. One randomized controlled trial was included in this report comparing skin preparation to no skin preparation prior to injection. No relevant cost-effectiveness studies or evidence-based guidelines were identified regarding preparing the skin for injection.

Authorisation for the return of products which fail to meet current published manufacturer’s specifications must be requested in writing within 28 days of delivery. VWR will assist customers, at customers’ expense, to obtain any manufacturer’s warranty consistent with that granted to VWR. The customer is responsible for unloading and transporting large and/or heavy items from delivery vans and for supervising the unloading of all other products delivered. Inclusion criteria: Healthy children aged zero to 18 years who qualified for vaccination in accordance with the Ontario Immunization Schedule were eligible. This document is prepared and intended for use in the context of the Canadian health care system. The use of this document outside of Canada is done so at the user’s own risk. VWR shall provide services to the customer in accordance with the specification agreed between them from time to time. Such services will be provided with all reasonable care and skill.The customer shall cooperate with VWR in all matters relating to the services, provide all such access and information as is necessary and obtain any licences permissions and consents required before commencement of the services. This is the first RCT to specifically examine the effect of alcohol swab skin cleansing on the incidence of local skin reactions and infection in children undergoing vaccine injections. We found no evidence of a difference in the rate of local skin reactions and no cases of cellulitis or infectious abscess when alcohol swabs were and were not used” (pp997) Customers who exceed their credit limits will be asked to pay in advance for additional products and/or services until the account is settled.